Dyslipidemia and gall stone disease; A search for their causal relationship. DİSLİPİDEMİ VE SAFRATAŞI HASTALIĞI; OLAĞAN İLİŞKİLERİYLE İLGİLİ BİR ÇALIŞMA.

  • Jay Kumar
  • Souvik Chatterjee
  • Swarupa Dinda
  • Anupama Ghosh
  • Nisith Ranjan Mallick
  • Quazi M Rahman
Keywords: Cholecystectomy, dyslipidemia, gall stone disease, lipid profile, lifestyle, triglycerides

Abstract

The study was conducted with the aim of exploring any possible relationship between gall stone disease and lipid profile.

Patients of any age or gender admitted for cholecystectomy due to gall stones (n=100) were kept in the study group while those admitted for reasons other than gall stone disease (n=100) were included as controls. Patients with history of intake of any hypolipidemic agents and diabetics were excluded. The patients of both the groups were divided into 3 different age groups which were further sub-divided into male and female. Thorough medical histories of the patients were taken and estimation of serum lipid profile was done.

The study group (with gall stone disease) was found to have significantly high value of serum triglycerides (p <0.05) in all age groups in both genders. Total cholesterol and serum LDL was found to be higher in males > 20 years. A definite inverse relationship between serum high density lipoprotein and gall stone was also noted in both genders above 20 years of age.

In this study high serum triglycerides, total cholesterol, serum LDL and low serum HDL are shown to be significantly related to gall stone disease.

Özet

Bu çalışmada safrataşları ve dislipidemi ararsında bir ilişkinin olup olmadığı araştırılmıştır.

Safrataşı nedeniyle hastaneye müracaat eden 100 kişi ile başka nedenlerle hastaneye gelen ve safrataşı tesbit edilen 100 hasta çalışmaya alınmıştır. Lipid azaltıcı ilaç kullanan hastalar çalışmaya alınmadı. Hastalar 3 farklı yaş grubuna ve erkek kadın olarak bir diğer alt gruba tanımlandılar.

Çalışma grubunda (Safra taşı şikayeti ile gelen hastalar) bulunan bütün alt grup hastalarda serum trigliserid değerleri anlamlı derecede yüksek bulundu (<0.05). Total kolesterol ve serum LDL seviyesi 20 yaş üstü erkeklerde yüksek bulundu. Her iki cinste ve 20 yaş üstü hastalarda yüksek serum HDL ve safr taşı hastalığı arasında ters bir ilişki saptandı.

Bu çalışmada, yüksek serum trigliserid, total kolesterol ve serum LDL, düşük serum HDL değerleri ile safra taşı varlığı arasında kuvvetli bir ilişki olduğu ortaya konmuştur.

Author Biographies

Jay Kumar

Department of Urology, Calcutta National Medical College, Kolkata, India

Souvik Chatterjee

Department of Urology1, Calcutta National Medical College, Kolkata, India

Swarupa Dinda

Fellow IVF BIRTH Clinic, Kolkata, India

Anupama Ghosh

Department of Dermatology, Phoenix Hospital, Dankuni, India

Nisith Ranjan Mallick

Department of General Surgery, Calcutta National Medical College, Kolkata, India

Quazi M Rahman

Department of Urology, Calcutta National Medical College, Kolkata, India

Published
2016-12-27
Section
Articles